Leucovorin 15mg Injection


Leucovorin 15mg Injection is used to prevent the harmful effects of methotrexate (anticancer medicine). It is also used to treat overdose of methotrexate.

Leucovorin 15mg Injection is given as a slow injection into veins under the supervision of a doctor. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to.

Injection site reactions (pain, swelling, redness) are common side effects of this medicine. If these bother you or appear serious, let your doctor know. There may be ways of reducing or preventing them. Regular blood tests are required to check your blood cells and serum methotrexate concentration in blood.

Before taking it, tell your doctor if have seizures, liver, or kidney problems or are taking any medicines to treat infections. Many other medicines can affect, or be affected by, this medicine so let your healthcare team know all medications you are using, especially phenytoin for your seizures. This medicine is not recommended during pregnancy or while breastfeeding.

Uses of Leucovorin Injection

  • Harmful effects of methotrexate

Side effects of Leucovorin Injection

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Leucovorin

  • Injection site reactions (pain, swelling, redness)

How to use Leucovorin Injection

Your doctor or nurse will give you this medicine. Kindly do not self administer.

How Leucovorin Injection works

Leucovorin 15mg Injection is a form of vitamin B. It works by protecting healthy cells from the toxic effects of methotrexate (anticancer medicine) while allowing it to enter and kill the cancer cells.

Safety Advice


It is not known whether it is safe to consume alcohol with Leucovorin 15mg Injection. Please consult your doctor.


Leucovorin 15mg Injection may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.


Information regarding the use of Leucovorin 15mg Injection during breastfeeding is not available. Please consult your doctor.


Leucovorin 15mg Injection does not usually affect your ability to drive.


There is limited information available on the use of Leucovorin 15mg Injection in patients with kidney disease. Please consult your doctor.


There is limited information available on the use of Leucovorin 15mg Injection in patients with liver disease. Please consult your doctor.

What if you forget to take Leucovorin Injection?

If you miss a dose of Leucovorin 15mg Injection, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.